![]() ![]() Chromium may increase its own toxicity by modifying metal regulatory transcription factor 1, causing the inhibition of zinc-induced metallothionein transcription. It can also cause transcriptional repression by cross-linking histone deacetylase 1-DNA methyltransferase 1 complexes to CYP1A1 promoter chromatin, inhibiting histone modification. It has been shown to induce carcinogenesis by overstimulating cellular regulatory pathways and increasing peroxide levels by activating certain mitogen-activated protein kinases. Trivalent chromium may also form complexes with peptides, proteins, and DNA, resulting in DNA-protein crosslinks, DNA strand breaks, DNA-DNA interstrand crosslinks, chromium-DNA adducts, chromosomal aberrations and alterations in cellular signaling pathways. chromium coordination entity ( CHEBI:86204 ).These are inorganic compounds in which the largest oxoanion is nitrate, and in which the heaviest atom not in an oxoanion is a transition metal. ()=O.()=O.()=Oīelongs to the class of inorganic compounds known as transition metal nitrates. Nitrite is a toxic compound known to cause methemoglobinemia. Trivalent chromium (chromium(III)) however, is biologically necessary for sugar and lipid metabolism in humans. ( 12)) due to its greater ability to enter cells and higher redox potential. Chromium is most toxic in its +6 oxidation state (chromiumNitrite is a toxic compound known to cause methemoglobinemia. It is found naturally occuring in rocks, animals, plants, and soil, and is usually mined as chromite ore. Chromium is a chemical element which has the symbol Cr and atomic number 24. It is used in the production of alkali metal-free catalysts and in pickling. Chromium nitrate is a nitrate of chromium. ![]()
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